An intimate relationship exists between physics and biology, beginning with the formation of the first cell from lipids delivered by snowball-like asteroids during the formation of Earth’s oceans. Lipids spontaneously form primitive ‘cells’, or micelles, when immersed in water. Regulated by homeostasis, micelles with semi-permeable membranes can produce energy through chemiosmosis (Mitchell 1961), maintaining negentropy, or energetic order within themselves (Schrodinger 1944). That threesome is termed the First Principles of Physiology (FPPs) (Torday JS, Rehan 2009), which enable life to circumvent the Second Law of Thermodynamics. That Faustian ‘pact with the devil’ allows for the free will to test those constraints based on the third of the First Principles, homeostasis, whereas the first two principles are determined. The same deterministic-probabilistic relationships also apply in physics, based on the Pauli Exclusion Principle, i.e., no two electrons in an atom can have the same values for the four quantum numbers that determine electron spin; the first three quantum numbers are determined, the fourth is probabilistic. We live within those biologic and physical boundaries, among which is moral behavior. Coordination of ‘good behavior’ is largely conditioned by our endocrine and neuroendocrine hormones, which either maintain or re-establish overall body-wide processes of homeostasis, referred to as allostasis. In the aggregate such body-wide control of homeostasis constitutes our behaviors, which mediate the collection of epigenetic data, which are assimilated by the organism in its germ cells (egg and sperm) as DNA adducts, which affect the structure and function of the offspring in order to adapt to the changes detected in the environment in order to maintain equipoise with the environment, or what we refer to as evolution.
Published on 14 July 2021