Humans no longer fit to the Darwinian theory, which recognized only random mutation as part of the evolutionary process.
Humans are now able to self-mutate at the level of genes.
This puts them outside the naturally evolving biologic systems described and theorized by Darwin. And, indeed, outside those of all other living organisms in the known universe.
Do we need a new theory of evolution? Or have humans become a new "boundary" (as per Steffens et al in Anthropocene article) in planetary systems?